Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8B40M)

• Drug Name: ONC-392 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Non-small-cell lung cancer	2C25.Y	Phase 1	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DM8B40M

Molecule-Related Drug Atlas

Drug(s) Targeting Cytotoxic T-lymphocyte protein 4 (CTLA-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ipilimumab	DMJTIYK	Melanoma	2C30	Approved	[3]
Tremelimumab	DMOQ9H1	Hepatocellular carcinoma	2C12.02	Approved	[4]
KN046	DMSDBPG	Non-small-cell lung cancer	2C25.Y	Phase 3	[5]
AK04	DMU7K86	Actinic keratosis	EK90.0	Phase 3	[6]
AK104	DMXJ8Z4	Cervical cancer	2C77.0	Phase 2	[7]
Lorigerlimab	DM2E8Z5	Prostate cancer	2C82.0	Phase 2	[8]
Vudalimab	DMSEEI0	Prostate cancer	2C82.0	Phase 2	[9]
AGEN1884	DMAP5B4	Cervical cancer	2C77.0	Phase 1/2	[10]
BMS-986288	DMM10J4	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[11]
MK-1308	DM25QKC	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cytotoxic T-lymphocyte protein 4 (CTLA-4)	TTI2S1D	CTLA4_HUMAN	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT04140526) Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC (PRESERVE-001). U.S. National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of OncoImmune.
• [3] Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2743).
• [5] Clinical pipeline report, company report or official report of Alphamab Oncology.
• [6] A multicenter, open-label phase Ib/II study of cadonilimab (anti PD-1 and CTLA-4 bispecific antibody) monotherapy in previously treated advanced non-small-cell lung cancer (AK104-202 study). Lung Cancer. 2023 Oct;184:107355.
• [7] Clinical pipeline report, company report or official report of Akeso Biopharma.
• [8] Clinical pipeline report, company report or official report of MacroGenics
• [9] Clinical pipeline report, company report or official report of Xencor
• [10] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [11] Clinical pipeline report, company report or official report of CytomX Therapeutics.
• [12] Safety and efficacy of quavonlimab, a novel anti-CTLA-4 antibody (MK-1308), in combination with pembrolizumab in first-line advanced non-small-cell lung cancer. Ann Oncol. 2021 Mar;32(3):395-403.