Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8LS3I)

Drug Name
PMID30247903-Compound-General structure19 Drug Info
Synonyms PMID30247903Compound19
Cross-matching ID
TTD Drug ID
DM8LS3I

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting PD-1-PD-L1 interaction (PD-1/PD-L1 PPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Macrocycle derivative 6 DMQ84KW Hepatitis DB97.Z Patented [2]
PMID30107136-Compound-Example12 DMN2K10 Hepatitis DB97.Z Patented [2]
Macrocycle derivative 1 DMN7I9C Hepatitis DB97.Z Patented [2]
Macrocycle derivative 9 DMARU0E Hepatitis DB97.Z Patented [2]
Macrocycle derivative 2 DM5OEQZ Hepatitis DB97.Z Patented [2]
Biaryl compound 1 DMHEAJQ Hepatitis DB97.Z Patented [2]
Macrocycle derivative 3 DMYGFTI Hepatitis DB97.Z Patented [2]
PMID30107136-Compound-Example11 DMD65GU Hepatitis DB97.Z Patented [2]
Macrocycle derivative 8 DMOMTBE Hepatitis DB97.Z Patented [2]
Biaryl compound 2 DMS8VYE Hepatitis DB97.Z Patented [2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) TT23XQV PDCD1_HUMAN-PD1L1_HUMAN Inhibitor [1]

References

1 Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730.
2 A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678.