Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8LS6H)

Drug Name

2-tosylbenzene-1,4-diol Drug Info

Synonyms

2-tosylbenzene-1,4-diol; 2-Tosylhydroquinone; 30958-16-8; CHEMBL462375; 2-(4-Methylbenzenesulfonyl)benzene-1,4-diol; 2-[(4-methylphenyl)sulfonyl]benzene-1,4-diol; AC1LDN5E; CBMicro_029952; Cambridge id 5869439; Oprea1_104843; Oprea1_717162; SCHEMBL10489221; ZINC36613; MolPort-015-161-937; JDVLOEPBUIGUKP-UHFFFAOYSA-N; MolPort-000-279-703; BDBM50245925; STK739706; AKOS000727738; MCULE-7472387969; BAS 00095777; ST001815; BIM-0030021.P001; 2-(Toluene-4-sulfonyl)-benzene-1,4-diol; 2-(4-methylphenyl)sulfonylbenzene-1,4-diol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 621969
CAS Number: CAS 30958-16-8
TTD Drug ID: DM8LS6H

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thiolactomycin	DMBAWDG	Malaria	1F40-1F45	Investigative	[2]
2-(4-Bromo-3-phenoxy-benzoylamino)-benzoic acid	DMY8GZP	Discovery agent	N.A.	Investigative	[3]
2-(4-Fluoro-3-phenoxy-benzoylamino)-benzoic acid	DMGLEX5	Discovery agent	N.A.	Investigative	[3]
2-Hydroxy-6-(3-phenoxy-benzoylamino)-benzoic acid	DMB3Y8H	Discovery agent	N.A.	Investigative	[3]
2-Tosylnaphthalene-1,4-diol	DM5FHO4	Discovery agent	N.A.	Investigative	[1]
2-(p-tolylthio)naphthalene-1,4-dione	DMON1A5	Discovery agent	N.A.	Investigative	[1]
2-tosylnaphthalene	DM2OUG0	Discovery agent	N.A.	Investigative	[1]
2-(4-propylphenylsulfonyl)naphthalene-1,4-diol	DMXC20R	Discovery agent	N.A.	Investigative	[1]
2-tosylanthracene-1,4-diol	DMOFDVE	Discovery agent	N.A.	Investigative	[1]
2-(4-chlorophenylsulfonyl)naphthalene-1,4-diol	DMJORCV	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH)	TTRVTMX	FABH_ECOLI	Inhibitor	[1]

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References

1	Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5.
2	The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51.
3	Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial age... J Med Chem. 2005 Mar 10;48(5):1596-609.