Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8OAN9)

Drug Name

CGK733 Drug Info

Synonyms

CGK733; 905973-89-9; CGK 733; CGK-733; 2,2-Diphenyl-N-(2,2,2-trichloro-1-(3-(4-fluoro-3-nitrophenyl)thioureido)ethyl)acetamide; CHEMBL1221601; 2,2-Diphenyl-n-(2,2,2-trichloro-1-[3-(4-fluoro-3-nitrophenyl)thioureido]ethyl)acetamide; UNII-L3DGZ99QYM; 2,2-diphenyl-N-(2,2,2-trichloro-1-{[(4-fluoro-3-nitrophenyl)carbamothioyl]amino}ethyl)acetamide; 2,2-diphenyl-N-[2,2,2-trichloro-1-[(4-fluoro-3-nitrophenyl)carbamothioylamino]ethyl]acetamide; L3DGZ99QYM

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6605258
ChEBI ID: CHEBI:91739
CAS Number: CAS 905973-89-9
TTD Drug ID: DM8OAN9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Serine/threonine-protein kinase ATR (FRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZD6738	DM0PFNC	Small-cell lung cancer	2C25.Y	Phase 2	[3]
RP-3500	DM9FNC8	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[4]
Camonsertib	DMOPPXY	Aggressive cancer	2A00-2F9Z	Phase 1/2	[5]
BAY1895344	DML781M	Lymphoma	2A80-2A86	Phase 1	[6]
VX-970	DMR9PCT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
M4344	DMQBO3V	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
M1774	DMP8QY2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
AZ20	DMNQ3HV	Discovery agent	N.A.	Investigative	[9]
VE-821	DM0UXNF	Solid tumour/cancer	2A00-2F9Z	Investigative	[7]
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⏷ Show the Full List of 9 Drug(s)

Drug(s) Targeting ATM serine/threonine kinase (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZD1390	DMYBX4N	Recurrent glioblastoma	2A00.00	Phase 1	[6]
M3541	DMG98QO	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
AZD0156	DMWCJEU	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
KU-60019	DMWA5XP	Non-small-cell lung cancer	2C25.Y	Clinical trial	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ATM serine/threonine kinase (ATM)	TTKBM7V	ATM_HUMAN	Inhibitor	[2]
Serine/threonine-protein kinase ATR (FRP1)	TT8ZYBQ	ATR_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5929).
2	Small molecule-based reversible reprogramming of cellular lifespan. Nat Chem Biol. 2006 Jul;2(7):369-74.
3	National Cancer Institute Drug Dictionary (drug id 754022).
4	Clinical pipeline report, company report or official report of Repare Therapeutics.
5	Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results. Nat Med. 2023 Jun;29(6):1400-1411.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 2014 Dec 1;74(23):6968-79.
8	National Cancer Institute Drug Dictionary (drug name M1774).
9	Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. J Med Chem. 2013 Mar 14;56(5):2125-38.
10	Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8(10):2894-902.