General Information of Drug (ID: DM8RHST)

Drug Name
QAP-642 Drug Info
Synonyms CCR3 antagonist (allergic rhinitis), Novartis
Indication
Disease Entry ICD 11 Status REF
Allergic rhinitis CA08.0 Terminated [1]
Cross-matching ID
TTD Drug ID
DM8RHST

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AKST4290 DM27ZJG Parkinson disease 8A00.0 Phase 2 [3]
AZD-1744 DMCOMG5 Asthma CA23 Discontinued in Phase 1 [4]
DPC-168 DMA7DH0 Allergic rhinitis CA08.0 Discontinued in Phase 1 [5]
YM-344031 DMMUYC2 Asthma CA23 Preclinical [6]
YM-355179 DMTM1LK Asthma CA23 Preclinical [6]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
C-C chemokine receptor type 3 (CCR3) TTD3XFU CCR3_HUMAN Antagonist [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023202)
2 New Drugs and Targets for Asthma and COPD. T.T. Hansel, P.J. Barnes. 2010. Page 158.
3 SAFETY AND THERAPEUTIC EFFECTS OF ORALLY ADMINISTERED AKST4290 IN NEWLY DIAGNOSED NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Retina. 2022 Jun 1;42(6):1038-1046.
4 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
5 CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2992-7.
6 Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.