General Information of Drug (ID: DM8T6VG)

Drug Name
PMID19831390C22m Drug Info
Synonyms GTPL8153; BDBM50299619
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44543082
TTD Drug ID
DM8T6VG

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID22902653C30 DMXDTPL Discovery agent N.A. Investigative [2]
PMID22902653C31 DMWVTAE Discovery agent N.A. Investigative [2]
PMID22902653C35 DMLVKPG Discovery agent N.A. Investigative [2]
PMID19831390C14 DMIECOF Discovery agent N.A. Investigative [1]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
LIM domain kinase-2 (LIMK-2) TTASMD8 LIMK2_HUMAN Inhibitor [1]

References

1 Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52(21):6515-8.
2 Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8.