Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8WJQ0)

Drug Name

PNT-300 Drug Info

Synonyms

KRAS gene inhibitor (cancer), ProNAi

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting KRAS messenger RNA (KRAS mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 6958	DM83EK9	Discovery agent	N.A.	Investigative	[2]
ISIS 7453	DMOX7FJ	Discovery agent	N.A.	Investigative	[2]
ISIS 6957	DMTHO4A	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2824).
2	US patent application no. 5,965,722, Antisense inhibition of ras gene with chimeric and alternating oligonucleotides.
3	Antisense oligonucleotides demonstrate a dominant role of c-Ki-RAS proteins in regulating the proliferation of diploid human fibroblasts. J Biol Chem. 1996 Nov 8;271(45):28259-65.