Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM90AG2)

Drug Name

Ularitide Drug Info

Synonyms

Urodilatin; 115966-23-9; Atriopeptin (95-126); Human urodilatin; Urodilatin human; Ularitide [INN]; Urodilatin ularitide; Anf (95-126); Anp (95-126); ANP 95-126; Atrial natriuretic peptide (95-126); CHEMBL2103920; Urodilatin human, > AKOS030213250; DB05034; CDD 95-126; LS-187531; LS-186876; Thr-Ala-Pro-Arg-Atrial Natriuretic Peptide; atrial natriuretic factor prohormone (95-126)

Indication

Disease Entry	ICD 11	Status	REF
Acute heart failure	BD10-BD13	Phase 3	[1]
Heart failure	BD10-BD13	Phase 3	[2]

Cross-matching ID

PubChem CID: 16132416
CAS Number: CAS 118812-69-4
TTD Drug ID: DM90AG2

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Atrial natriuretic peptide receptor A (NPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nesiritide	DMFOIA8	Congestive heart failure	BD10	Approved	[4]
Ataciguat	DM35KDA	Neuropathic pain	8E43.0	Phase 2	[5]
Cenderitide	DMCT8EY	Heart disease	BA41-BA42	Phase 2	[6]
PL-3994	DMHUCQS	Asthma	CA23	Phase 2	[7]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Atrial natriuretic peptide receptor A (NPR1)	TTJME02	ANPRA_HUMAN	Modulator	[3]

------------------------------------------------------------------------------------

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8446).
3	Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies. Eur Heart J. 2015 Mar 21;36(12):715-23.
4	The efficacy and safety of B-type natriuretic peptide (nesiritide) in patients with renal insufficiency and acutely decompensated congestive heart failure. Nephrol Dial Transplant. 2004 Feb;19(2):391-9.
5	Pharma & Vaccines. Product Development Pipeline. April 29 2009.
6	2011 Pipeline of Nile Therapeutics.
7	In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH2) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pharmacol Ther. 2013 April; 26(2): 229-238.