Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM90GS3)

Drug Name

VK-0214 Drug Info

Synonyms

6FGG71NJ3Y; VK0214; VK-0214; UNII-6FGG71NJ3Y; (((4-(3-Benzyl-4-hydroxybenzyl)-3,5-dimethylphenyl)oxy)methyl)phosphonic acid; ((4-(3-Benzyl-4-hydroxybenzyl)-3,5-dimethylphenoxy)methyl)phosphonic acid; Phosphonic acid, P-((4-((4-hydroxy-3-(phenylmethyl)phenyl)methyl)-3,5-dimethylphenoxy)methyl)-; 852949-30-5; SCHEMBL283442; CHEMBL4802139

Indication

Disease Entry	ICD 11	Status	REF
X-linked Adrenoleukodystrophy	5C57	Phase 1	[1]

Cross-matching ID

PubChem CID: 15942270
TTD Drug ID: DM90GS3

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Thyroid hormone receptor beta (THRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dextrothyroxine Sodium	DMBVEC7	High blood cholesterol level	5C80.00	Approved	[3]
BCT303	DMUFY4K	Hypothyroidism	5A00	Phase 2	[4]
MB-07811	DM6JTSZ	Hyperlipidaemia	5C80	Phase 2	[5]
MGL-3196	DM1HC9R	Familial hypercholesterolemia	5C80.00	Phase 2	[6]
VK-2809	DMY5NUR	Hypercholesterolaemia	5C80.0	Phase 2	[7]
ZYT-1	DM1XOZK	Lipid metabolism disorder	5C52.Z	Phase 1	[4]
Axitirome	DM6L5IP	Hyperlipidaemia	5C80	Phase 1	[8]
tiratricol	DMZO6CV	Wound healing	EL8Y	Clinical trial	[9]
Cacodylate Ion	DMK4XLD	Discovery agent	N.A.	Investigative	[10]
3-(dibutylamino)-1-(4-hexylphenyl)propan-1-one	DM2JBQI	Discovery agent	N.A.	Investigative	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thyroid hormone receptor beta (THRB)	TTGER3L	THB_HUMAN	Agonist	[2]

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References

1	ClinicalTrials.gov (NCT04973657) Phase 1b, Multi-center, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Safety, Tolerability, PD and PK of VK0214, in Subjects With the Adrenomyeloneuropathy Form (AMN) of X-linked Adrenoleukodystrophy (X-ALD). U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of Viking Therapeutics
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 589).
6	Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-beta agonist. Atherosclerosis. 2013 Oct;230(2):373-80.
7	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8	Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors alpha-1 and beta-1. FEBS Open Bio. 2012; 2: 247-253.
9	Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. Mol Endocrinol. 1990 Feb;4(2):227-34.
10	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
11	Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80.