Details of the Drug-Related molecule(s) Interaction Atlas

PD-123319 Drug Info

PD123319; PD 123319; 130663-39-7; PD-123319; CHEBI:61014; C31H32N4O3; CHEMBL157946; (S)-1-(4-(dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid; (6S)-1-[4-(dimethylamino)-3-methylbenzyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid; AC1NSKGQ; Epitope ID:140138; GTPL597; SCHEMBL668525; CHEMBL321820; PD-123319 ditrifluoroacetate; MolPort-005-942-100; EX-A2290; BCP08027; s7098; 2633AH; ZINC22015557; BDBM50282396; AKOS030526087

Cross-matching ID

PubChem CID

5311345

ChEBI ID

CHEBI:61014

CAS Number

CAS 130663-39-7

TTD Drug ID

DM92VUF

General Information of Drug (ID: DM92VUF)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Discontinued Drug(s)

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Drug(s) Targeting Angiotensin II receptor type-2 (AGTR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ANGIOTENSIN II	DMLWQ27	Increase blood pressure	BA04	Approved	[2]
SARALASIN	DMKS1DV	Hypertension	BA00-BA04	Approved	[3]
EMA-401	DMYOUB6	Peripheral neuropathy	8C0Z	Phase 2	[4]
MP-157	DM5VXWO	Hypertension	BA00-BA04	Phase 1	[5]
PMID25416646-Compound-Figure5-E	DMYO7VH	N. A.	N. A.	Patented	[6]
Phenylpyridine derivative 3	DMDT5JI	N. A.	N. A.	Patented	[6]
1-(biphenyl-4-yl-methyl)-1H-imidazole derivative 1	DMGYZQ2	N. A.	N. A.	Patented	[6]
Fonsartan	DM15LAP	Hypertension	BA00-BA04	Discontinued in Phase 2	[7]
L-158282	DMKSEIY	N. A.	N. A.	Discontinued in Phase 2	[8]
TAK-591	DM25DB4	Hypertension	BA00-BA04	Discontinued in Phase 1	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin II receptor type-2 (AGTR2)	TTQVOEI	AGTR2_HUMAN	Inhibitor	[1]

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References

1	Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 sub... J Med Chem. 1991 Nov;34(11):3248-60.
2	The preparation of (perfluoroalkyl)imidazoles as nonpeptide angiotensin II receptor antagonists, Bioorg. Med. Chem. Lett. 3(5):895-898 (1993).
3	cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8.
4	Clinical pipeline report, company report or official report of Spinifex.
5	As drug target reemerges, the question is to block or stimulate it. Nature Medicine. Spoonful of Medicine. 05 Feb 2014. Cassandra Willyard
6	PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91.
7	Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats. J Hypertens. 1998 Dec;16(12 Pt 2):2039-43.
8	Subtituted phenylthiophene benzoylsulfonamides with potent binding affinity to angiotensin II AT1 and AT2 receptors, Bioorg. Med. Chem. Lett. 4(1):189-194 (1994).
9	Clinical pipeline report, company report or official report of Takeda (2009).