Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9OXEJ)

Drug Name

BIIB 023 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting TNF-related weak inducer of apoptosis (TWEAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RO-5458640	DMVXQ5W	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TNF-related weak inducer of apoptosis (TWEAK)	TTBTDM1	TNF12_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01930890) BIIB023 Long-Term Extension Study in Subjects With Lupus Nephritis. U.S. National Institutes of Health.
2	ClinicalTrials.gov (NCT00771329) BIIB023 (Anti-TWEAK) in Subjects With Rheumatoid Arthritis. U.S. National Institutes of Health.
3	A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo. MAbs. 2014 January 1; 6(1): 297-308.