Details of the Drug

General Information of Drug (ID: DMVXQ5W)

Drug Name

RO-5458640

Synonyms

Anti-TWEAK humanized monoclonal antibody (iv, cancer), Hoffmann-La Roche

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
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Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TNF-related weak inducer of apoptosis (TWEAK)	TTBTDM1	TNF12_HUMAN	Modulator	[2]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT01383733) A Study of RO5458640 in Patients With Advanced Solid Tumors. U.S. National Institutes of Health.
2	A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo. MAbs. 2014 January 1; 6(1): 297-308.