Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9U1HV)

Drug Name

5-fluoro-1H-indole-2-carboxylic acid Drug Info

Synonyms

5-Fluoroindole-2-carboxylic acid; 399-76-8; 5-Fluoro-1H-indole-2-carboxylic acid; 2-Carboxy-5-fluoroindole; 1H-Indole-2-carboxylic acid, 5-fluoro-; CHEMBL23507; MLS000080089; WTXBRZCVLDTWLP-UHFFFAOYSA-N; MFCD00005612; SMR000037735; 5-Fluoroindole-2-carboxylic acid, 98%; Spectrum_001495; EINECS 206-919-5; PubChem1683; SpecPlus_000678; Spectrum5_001733; Opera_ID_1340; Spectrum4_001182; Spectrum3_001043; Spectrum2_001469; ACMC-209j9k; AC1Q4NE3; Lopac-265128; cid_1820; AC1Q73TI; AC1L1CB9; AC1Q73TJ; Lopac0_000071; Oprea1_012690

Indication

Disease Entry	ICD 11	Status	REF
Glioma	2A00.0	Investigative	[1]
Melanoma	2C30	Investigative	[1]

Cross-matching ID

PubChem CID: 1820
ChEBI ID: CHEBI:111276
CAS Number: CAS 399-76-8
TTD Drug ID: DM9U1HV

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting AP endonuclease 1 (APEX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
APX3330	DMU6NBO	Diabetic retinopathy	9B71.0	Phase 2	[2]
APX-3330	DMXIMQT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
1,3-bis(1,3-benzothiazol-2-ylthio)acetone	DMP86R3	Glioma	2A00.0	Investigative	[1]
3-benzofuran-2-yl-2-benzothiazol-2-yl-3-oxo-propanenitrile	DMWLIK1	Glioma	2A00.0	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
AP endonuclease 1 (APEX1)	TTHGL48	APEX1_HUMAN	Inhibitor	[1]

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References

1	Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines. Br J Cancer. 2011 Feb 15;104(4):653-63.
2	Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic. NPJ Precis Oncol. 2017;1:19.
3	Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo. Vision Res. 2011 Jan;51(1):93-100.