Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9XV16)

Drug Name

Sanguiin H-6 Drug Info

Synonyms

Sanguiin H-6; CHEMBL508647; CHEMBL3734788; BDBM50250999; [[5-[dodecahydroxy(tetraoxo)[ ]yl]oxycarbonyl-2,3-dihydroxy-phenoxy]-dodecahydroxy-tetraoxo-[ ]yl] 3,4,5-trihydroxybenzoate; .alpha.-D-Glucopyranose, cyclic 4,6-[3-[5-[[[2,3:4,6-bis-O-[(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-diyl)dicarbonyl]-.beta.-D-glucopyranosyl]oxy]carbonyl]-2,3-dihydroxyphenoxy]-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] cyclic 2,3-(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate) 1-(3,4,5- trih

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 16130897
TTD Drug ID: DM9XV16

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Naftifine	DMHVBG1	Dermatomycosis	EA60	Approved	[2]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[1]
FR-194738	DMNACIV	Hypercholesterolaemia	5C80.0	Terminated	[4]
SDZ-87-469	DMBY6CQ	Coronary artery disease	BA80	Terminated	[3]
NB-598	DMJVTQN	N. A.	N. A.	Terminated	[5]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[1]
1,2,3,4,6-penta-O-galloyl-beta-D-glucose	DMTK650	Discovery agent	N.A.	Investigative	[1]
Pedunculagin	DMKLRCX	Discovery agent	N.A.	Investigative	[1]
CORILAGIN	DMAC698	Discovery agent	N.A.	Investigative	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Squalene monooxygenase (SQLE)	TTE14XG	ERG1_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4.
2	Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Antimicrob Agents Chemother. 1996 Feb;40(2):443-7.
3	Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother. 1992 Aug;36(8):1779-81.
4	Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738. Bioorg Med Chem Lett. 2004 Feb 9;14(3):633-7.
5	Squalene epoxidase as hypocholesterolemic drug target revisited. Prog Lipid Res. 2003 Jan;42(1):37-50.