Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA25NO)

Drug Name

MK-4214 Drug Info

Synonyms

INS-19; Recombinant human GCSF (biosimilar), Insmed

Indication

Disease Entry	ICD 11	Status	REF
Neutropenia	4B00.0	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Granulocyte colony-stimulating factor (CSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eflapegrastim	DMACVEI	Neutropenia	4B00.0	Approved	[3]
Efbemalenograstim	DMDNJ18	Neutropenia	4B00.0	Approved	[4]
Interleukin-3	DM1Y69Q	Aplastic anemia	3A70	Approved	[5]
Neugranin	DMLRKJX	Neutropenia	4B00.0	Preregistration	[6]
DA-3031	DM6S4R2	Neutropenia	4B00.0	Phase 3	[7]
LA-EP2006	DMI3YLK	Neutropenia	4B00.0	Phase 3	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Granulocyte colony-stimulating factor (CSF3)	TT5TQ2W	CSF3_HUMAN	Modulator	[2]

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References

1	Clinical pipeline report, company report or official report of Merck.
2	DOI: 10.1038/nbt0710-636a
3	Company report (Sppirx)
4	Clinical pipeline report, company report or official report of Generon (Shanghai) Corporation Ltd.
5	Interleukin 3: from colony-stimulating factor to pluripotent immunoregulatory cytokine. Int J Immunopharmacol. 1992 Apr;14(3):421-30.
6	Development and Characterization of a Novel Fusion Protein of a Mutated Granulocyte Colony-Stimulating Factor and Human Serum Albumin in Pichia pastoris. PLoS One. 2014; 9(12): e115840.
7	A randomized, multi-center, open-label, phase II study of once-per-cycle DA-3031, a biosimilar pegylated G-CSF, compared with daily filgrastim in patients receiving TAC chemotherapy for early-stage breast cancer.Invest New Drugs.2013 Oct;31(5):1300-6.
8	National Cancer Institute Drug Dictionary (drug id 724518).