Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA368V)

Drug Name

MGD010 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune disease	4A40-4A45	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Immunoglobulin gamma Fc receptor IIB (FCGR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Xmab 5871	DMLIPY1	Autoimmune diabetes	5A10	Phase 2	[2]
BI 1206	DMTOMWB	B-cell lymphoma	2A86	Phase 1/2	[3]
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Drug(s) Targeting B-cell-specific glycoprotein B29 (CD79B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Polatuzumab vedotin	DMF6Y0L	Diffuse large B-cell lymphoma	2A81	Approved	[4]
RG7596	DMVXGU0	Haematological malignancy	2B33.Y	Phase 2	[5]
DCDS-4501A	DMQRCX5	Diffuse large B-cell lymphoma	2A81	Phase 2	[6]
Polivy	DMFCIKN	Mantle cell lymphoma	2A85.5	Phase 2	[7]
CD79-targeted immunotoxins	DMWP63C	Non-hodgkin lymphoma	2B33.5	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
B-cell-specific glycoprotein B29 (CD79B)	TTBN5I7	CD79B_HUMAN	Modulator	[1]
Immunoglobulin gamma Fc receptor IIB (FCGR2B)	TT5RWKQ	FCG2B_HUMAN	Modulator	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	CD19 as an attractive target for antibody-based therapy. MAbs. 2012 Sep-Oct;4(5):571-7.
3	Clinical pipeline report, company report or official report of BioInvent.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2852).
6	Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development. Mar Drugs. 2014 January; 12(1): 255-278.
7	Polatuzumab Vedotin: First Global Approval. Drugs. 2019 Sep;79(13):1467-1475.