Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA4U2P)

Drug Name

ISIS 28472 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Smad7 messenger RNA (Smad7 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GED-0301	DMTUV7L	Crohn disease	DD70	Phase 3	[2]
ISIS 28466	DMH96UP	Discovery agent	N.A.	Investigative	[1]
ISIS 28477	DMMOV9U	Discovery agent	N.A.	Investigative	[1]
ISIS 28465	DMQ5JNT	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	US patent application no. 6,159,697, Antisense modulation of Smad7 expression.
2	A phase 1 open-label trial shows that smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease. Aliment Pharmacol Ther. 2012 Nov;36(9):850-7.