Details of the Drug

General Information of Drug (ID: DMTUV7L)

Drug Name
GED-0301
Synonyms SMAD-7 inhibitor (oligonucleotide, Crohn's disease), Giuliani
Indication
Disease Entry ICD 11 Status REF
Crohn disease DD70 Phase 3 [1]
Ulcerative colitis DD71 Phase 2 [1]
Cross-matching ID
PubChem CID
121490254
TTD ID
D09FKY
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Mothers against decapentaplegic homolog 7 (SMAD7) TTW06P4 SMAD7_HUMAN Inhibitor [1]
Smad7 messenger RNA (Smad7 mRNA) TT0J32Z SMAD7_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 A phase 1 open-label trial shows that smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease. Aliment Pharmacol Ther. 2012 Nov;36(9):850-7.