Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAEWS1)

Drug Name

GAM-501 Drug Info

Synonyms

Excellarate; Diabetic ulcer product, Selective Genetics; AdPDGF-B/GAM; Adenoviral gene therapy (PDGF-B), Selective Genetics; PDGF-B adenoviral gene therapy (collagen gel, diabetic foot ulcer), Tissue Repair Company

Indication

Disease Entry	ICD 11	Status	REF
Diabetic foot ulcer	BD54	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMAEWS1

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Platelet-derived growth factor B (PDGFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PDGF-BB	DMMBC5W	Diabetic foot ulcer	BD54	Phase 3	[3]
E-10030	DMDYWM8	Macular degeneration	9B78.3	Phase 2	[4]
CR-002	DMKWSFI	Cystic fibrosis	CA25	Phase 1	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Platelet-derived growth factor B (PDGFB)	TTQA6SX	PDGFB_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT00493051) Phase 2b Study of GAM501 in the Treatment of Diabetic Ulcers of the Lower Extremities. U.S. National Institutes of Health.
2	Treatment of nonhealing diabetic foot ulcers with a platelet-derived growth factor gene-activated matrix (GAM501): results of a phase 1/2 trial. Wound Repair Regen. 2009 Nov-Dec;17(6):772-9.
3	Clinical pipeline report, company report or official report of Adocia.
4	Aptamers as therapeutics. Nat Rev Drug Discov. 2010 Jul;9(7):537-50.
5	A phase I study of CR002, a fully-human monoclonal antibody against platelet-derived growth factor-D. Int J Clin Pharmacol Ther. 2008 May;46(5):236-44.