General Information of Drug (ID: DMAGI7K)

Drug Name
TNFcept Drug Info
Synonyms TNFcept (rheumatoid arthritis)
Indication
Disease Entry ICD 11 Status REF
Rheumatoid arthritis FA20 Investigative [1]
Cross-matching ID
TTD Drug ID
DMAGI7K

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
VB-111 DMX04CA Malignant glioma 2A00.0 Phase 3 [2]
Drug 2862277 DM8WU3O Acute lung injury NB32.3 Phase 2 [3]
AVX-470 DMAKD0I Inflammatory bowel disease DD72 Phase 1 [1]
GSK1995057 DMC14KV Adult respiratory distress syndrome CB00 Phase 1 [4]
Anti-IFN gamma DMXI185 Alopecia ED70 Terminated [1]
TNFR1 NAM DMPTQEG Multiple sclerosis 8A40 Investigative [3]
NM-9405 DMKMBSJ Rheumatoid arthritis FA20 Investigative [3]
TNFmab DM4T0ZF Rheumatoid arthritis FA20 Investigative [1]
ADS-0101 DMP7IS0 Chronic obstructive pulmonary disease CA22 Investigative [3]
Recombinant human TNF receptor DMLYQWV Arthritis FA20 Investigative [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tumor necrosis factor receptor type I (TNF-R1) TTG043C TNR1A_HUMAN Modulator [1]

References

1 Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65.
2 Phase I dose-escalation study of VB-111, an antiangiogenic virotherapy, in patients with advanced solid tumors.Clin Cancer Res.2013 Jul 15;19(14):3996-4007.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1870).
4 Autoantibodies to variable heavy (VH) chain Ig sequences in humans impact the safety and clinical pharmacology of a VH domain antibody antagonist of TNF-alpha receptor 1. J Clin Immunol. 2013 Oct;33(7):1192-203.