Details of the Drug

General Information of Drug (ID: DMAKD0I)

Drug Name
AVX-470
Synonyms Anti-TNF antibody (oral, IBD), Avaxia Biologics
Indication
Disease Entry ICD 11 Status REF
Inflammatory bowel disease DD72 Phase 1 [1]
Ulcerative colitis DD71 Phase 1 [2]
Drug Type
Antibody
Cross-matching ID
TTD ID
D03HIG
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tumor necrosis factor (TNF) TTF8CQI TNFA_HUMAN Inhibitor [2]
Tumor necrosis factor receptor type I (TNF-R1) TTG043C TNR1A_HUMAN Not Available [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT01759056) Evaluation of an Oral Anti-TNF Antibody in Patients With Active Ulcerative Colitis. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65.