Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAJNPS)

Drug Name

Coumermycin Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Bacterial DNA gyrase B (Bact gyrB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SPR720	DMJDV0K	Mycobacterium infection	1B10-1B21	Phase 1/2	[2]
BAY 50-7952	DM743XB	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial DNA gyrase B (Bact gyrB)	TTS7LWX	GYRB_ECOLI	Inhibitor	[1]

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References

1	Isolation and characterization of an Escherichia coli strain exhibiting partial tolerance to quinolones. Antimicrob Agents Chemother. 1989 May;33(5):705-9.
2	Advancement of GyrB Inhibitors for Treatment of Infections Caused by Mycobacterium tuberculosis and Non-tuberculous Mycobacteria. ACS Infect Dis. 2020 Jun 12;6(6):1323-1331.
3	seco-Cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties. J Med Chem. 2001 Feb 15;44(4):619-26.