General Information of Drug (ID: DMAKW2S)

Drug Name
Thiophene sulfonamide Drug Info
Synonyms
MLS000048634; AC1O9WJ4; AC1NX3H6; AC1NT7F3; N-(2-hydroxybenzylidene)-2-thiophenesulfonamide; CHEMBL3193745; MolPort-035-831-874; MolPort-000-689-338; CCG-13754; AKOS001033013; SMR000060871; ST021762; BIM-0024487P001; SR-01000030268; AS-871/40346888; SR-01000030268-1; 2-{[(1E)-2-(2-hydroxyphenyl)-1-azavinyl]sulfonyl}thiophene; N-[(Z)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]thiophene-2-sulfonamide; N-[(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]thiophene-2-sulfonamide
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Investigative [1]
Cross-matching ID
PubChem CID
72881
ChEBI ID
CHEBI:79403
CAS Number
CAS 6339-87-3
TTD Drug ID
DMAKW2S

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
KENPAULLONE DMAGVXW Discovery agent N.A. Patented [2]
APIGENIN DMI3491 Discovery agent N.A. Investigative [2]
2,5-dichloro-N-p-tolylthiophene-3-sulfonamide DMU5J8Y Discovery agent N.A. Investigative [3]
WR-289010 DMS2QUL Discovery agent N.A. Investigative [4]
WR-080539 DMUCGK8 Discovery agent N.A. Investigative [4]
5-chloro-4-nitrothiophene-2-sulfonamide DMRS82Q Discovery agent N.A. Investigative [3]
Oxindole derivative DM1AU8V Malaria 1F40-1F45 Investigative [5]
WR-203581 DM9M1UO Discovery agent N.A. Investigative [4]
WR-289009 DM5W9GR Discovery agent N.A. Investigative [4]
N-(2-aminoethyl)isoquinoline-5-sulfonamide DMG2MSX Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Plasmodium CDK Pfmrk (Malaria Pfmrk) TTSFWA7 P90584_PLAFA Inhibitor [1]

References

1 Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.
2 A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different class... J Med Chem. 2004 Oct 21;47(22):5418-26.
3 Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010).
4 Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5.
5 Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10.
6 Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4961-6.