General Information of Drug (ID: DMAO04B)

Drug Name
CEP-32496 Drug Info
Synonyms AB-024; B-RAF kinase inhibitors (melanoma), Ambit/Cephalon
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [1]
Cross-matching ID
PubChem CID
56846693
CAS Number
CAS 1188910-76-0
TTD Drug ID
DMAO04B
VARIDT Drug ID
DR00774

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Proto-oncogene c-Ret (RET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [4]
Regorafenib DMHSY1I Gastrointestinal stromal tumour 2B5B Approved [5]
Ponatinib DMYGJQO Acute lymphoblastic leukaemia 2A85 Approved [5]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [6]
Selpercatinib DMZR15V Non-small-cell lung cancer 2C25.Y Approved [7]
Pralsetinib DMWU0I2 Non-small-cell lung cancer 2C25.Y Approved [8]
MGCD516 DM752PU Solid tumour/cancer 2A00-2F9Z Phase 2/3 [9]
TPX-0046 DMIVE67 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [10]
GSK3179106 DM2KCIP Inflammatory bowel disease DD72 Phase 1 [11]
BOS172738 DM9L0D8 Solid tumour/cancer 2A00-2F9Z Phase 1 [12]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dabrafenib DMX6OE3 Melanoma 2C30 Approved [13]
Vemurafenib DM62UG5 Melanoma 2C30 Approved [5]
LGX818 DMNQXV8 Melanoma 2C30 Approved [14]
PLX8394 DMRTD7I Solid tumour/cancer 2A00-2F9Z Phase 2 [15]
BGB-283 DMVYTG7 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [16]
ARQ 736 DMP9ZT1 Solid tumour/cancer 2A00-2F9Z Phase 1 [17]
RO-5212054 DML4C3Q Solid tumour/cancer 2A00-2F9Z Phase 1 [18]
ASN003 DMJCX6D Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
BMS-908662 DM3K8VM Solid tumour/cancer 2A00-2F9Z Phase 1 [19]
ABM-1310 DMS1HR3 Solid tumour/cancer 2A00-2F9Z Phase 1 [20]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene c-Ret (RET) TT4DXQT RET_HUMAN Inhibitor [2]
Serine/threonine-protein kinase B-raf (BRAF) TTWCGQT BRAF_HUMAN Inhibitor [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7880).
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Clinical pipeline report, company report or official report of Ambit Biosciences.
4 Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1482-96.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
6 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
8 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
9 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2185).
10 Clinical pipeline report, company report or official report of Turning Point Therapeutics.
11 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
12 National Cancer Institute Drug Dictionary (drug name Zeteletinib).
13 Clinical pipeline report, company report or official report of GlaxoSmithKline (2011).
14 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
15 Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors. Pigment Cell Melanoma Res. 2014 Mar;27(2):253-62.
16 BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers. Mol Cancer Ther. 2015 Oct;14(10):2187-97.
17 National Cancer Institute Drug Dictionary (drug id 688029).
18 National Cancer Institute Drug Dictionary (drug id 680347).
19 Clinical pipeline report, company report or official report of Exelixis (2011).
20 Clinical pipeline report, company report or official report of ABM Therapeutics.