Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAQNBW)

Drug Name

AM103 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Arachidonate 5-lipoxygenase activating protein (FLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DG031	DMO3AJS	Asthma	CA23	Discontinued in Phase 3	[3]
GSK2190915	DM89AV2	Asthma	CA23	Discontinued in Phase 2	[4]
GSK2190914	DMHZQ0T	Asthma	CA23	Discontinued in Phase 2	[5]
AZD4769	DMA3OWI	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 1	[6]
A-93178	DM1KBAY	Allergy	4A80-4A85	Terminated	[7]
L-671,480	DMP4QCJ	Discovery agent	N.A.	Investigative	[8]
L-689,037	DMCH3ZK	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase activating protein (FLAP)	TTDMBF5	AL5AP_HUMAN	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026047)
2	AM103 Experimental Treatment for Respiratory Diseases. Amira Pharmaceuticals/GSK. 2009.
3	BAY x 1005 attenuates atherosclerosis in apoE/LDLR - double knockout mice. J Physiol Pharmacol. 2007 Sep;58(3):583-8.
4	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
5	FLAP inhibitors for the treatment of inflammatory diseases. Curr Opin Investig Drugs. 2009 Nov;10(11):1163-72.
6	5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Feb;41(2):267-72.
7	Characterization of A-93178, an iminoxy-quinoline inhibitor of leukotriene biosynthesis. Adv Exp Med Biol. 1997;433:91-4.
8	5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors. Mol Pharmacol. 1991 Jul;40(1):22-7.