Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAQU71)

Drug Name

Ins(3,4,5,6)P4 Drug Info

Synonyms

1D-myo-inositol 3,4,5,6-tetrakisphosphate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Calcium-dependent chloride channel anoctamin (ANO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzbromarone	DMC3YUA	Gout	FA25	Approved	[3]
Crofelemer	DM4AMQZ	HIV-associated diarrhoea	1A2Z	Approved	[4]
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[2]
DIDS	DMKSQUB	Discovery agent	N.A.	Investigative	[2]
9-anthroic acid	DMGCVT2	Discovery agent	N.A.	Investigative	[2]
SITS	DMCMIUG	Discovery agent	N.A.	Investigative	[2]
DCDPC	DMG9BFR	Discovery agent	N.A.	Investigative	[2]
tannic acid	DM52WGH	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium-dependent chloride channel anoctamin (ANO)	TTOJI4S	ANO1_HUMAN	Blocker (channel blocker)	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4224).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708).
3	Anoctamin Channels in Human Myometrium: A Novel Target for Tocolysis.Reprod Sci. 2018 Nov;25(11):1589-1600.
4	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.