Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMARIQK)

Drug Name

AT-527 Drug Info

Synonyms

AT527; SCHEMBL18061556; GTPL11295; 2241337-84-6; propan-2-yl (2S)-2-[[[(3R,4R,5R)-5-[2-amino-6-(methylamino)purin-9-yl]-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate

Indication

Disease Entry	ICD 11	Status	REF
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[1]

Cross-matching ID

PubChem CID: 122527270
TTD Drug ID: DMARIQK

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Virus RNA-dependent RNA polymerase (Viru RdRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyrophosphate 2-	DMZQ75M	Discovery agent	N.A.	Investigative	[3]
Guanosine-5'-Triphosphate	DMV2OJX	Discovery agent	N.A.	Investigative	[4]
Thiadiazolo[2,3-a]pyrimidine	DMKRG2C	Discovery agent	N.A.	Investigative	[5]
T-1105	DMGPQ0Y	Discovery agent	N.A.	Investigative	[5]
Pyrimidinyl acylthiourea	DM7T2VQ	Discovery agent	N.A.	Investigative	[5]
FdG	DMYXA7E	Discovery agent	N.A.	Investigative	[5]
T-1106	DMPA2E9	Virus infection	1A24-1D9Z	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Virus RNA-dependent RNA polymerase (Viru RdRP)	TTSUKYD	POLG_HCVJA	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT04709835) Study to Evaluate the Effects of AT-527 in Non-Hospitalized Adult Patients With Mild or Moderate COVID-19. U.S. National Institutes of Health.
2	AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02479-20.
3	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9.