Details of the Drug-Related molecule(s) Interaction Atlas

HSR-803 Drug Info

Ganaton; ITOPRIDE HCl; Itopride (hydrochloride); Q-201260; itopride hydrochloride; 122892-31-3; 2H9NV66W0I; C20H27ClN2O4; DSSTox_CID_26693; DSSTox_GSID_46693; DSSTox_RID_81827; HSR-803; HSR803; Hsr 803; Itax; MFCD00881710; N-((4-(2-(Dimethylamino)ethoxy)phenyl)methyl)-3,4-dimethoxybenzamide monohydrochloride; N-(4-(2-(Dimethylamino)ethoxy)benzyl)-3,4-dimethoxidebenzamide hydrochloride; N-(4-(2-(dimethylamino)ethoxy)benzyl)-3,4-dimethoxybenzmide; UNII-2H9NV66W0I; n-[4-(2-dimethylaminoethoxy)benzyl]-3,4-dimethoxybenzamide hcl

Cross-matching ID

PubChem CID

129791

CAS Number

CAS 122892-31-3

TTD Drug ID

DMAVIPZ

INTEDE Drug ID

DR0894

General Information of Drug (ID: DMAVIPZ)

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Metabolized By Dimethylaniline oxidase 3 (FMO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[2]
Ethionamide	DM8K3EI	Pulmonary tuberculosis	1B10.Z	Approved	[3]
Almotriptan malate	DMFG5ST	N. A.	N. A.	Approved	[4]
Fedratinib hydrochloride	DML2DCR	N. A.	N. A.	Approved	[5]
Itopride	DM7MLTR	N. A.	N. A.	Phase 3	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Dimethylaniline oxidase 3 (FMO3)^{Main DME}	DEP76YL	FMO3_HUMAN	Substrate	[1]

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References

1	Development of a physiologically based pharmacokinetic model to predict the effects of flavin-containing monooxygenase 3 (FMO3) polymorphisms on itopride exposure. Biopharm Drug Dispos. 2017 Sep;38(6):389-393.
2	Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39.
3	Physiologically based pharmacokinetic modeling approach to predict drug-drug interactions with ethionamide involving impact of genetic polymorphism on FMO3. J Clin Pharmacol. 2019 Jun;59(6):880-889.
4	Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11.
5	FDA label of Fedratinib. The 2020 official website of the U.S. Food and Drug Administration.