General Information of Drug (ID: DMB8U4F)

Drug Name
FPL64176 Drug Info
Synonyms FPL-64176; FPL 64176
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
3423
ChEBI ID
CHEBI:249982
CAS Number
CAS 120934-96-5
TTD Drug ID
DMB8U4F

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
(-)-(S)-BayK8644 DMEA9KH Discovery agent N.A. Investigative [2]
[3H](-)devapamil DM0KGHP Discovery agent N.A. Investigative [4]
[3H](+)-isradipine DM7QE1J Discovery agent N.A. Investigative [5]
[3H](+)-cis-diltiazem DMP6XL9 Discovery agent N.A. Investigative [6]
SZ(+)-(S)-202-791 DM8L6ZF Discovery agent N.A. Investigative [2]
Drug Name Drug ID Indication ICD 11 Highest Status REF
RAUWOLFIA SERPENTINA ROOT DMWTVAN Discovery agent N.A. Approved [7]
ARC029 DMYNJHI Alzheimer disease 8A20 Phase 3 [8]
SNAP-5089 DMROJEN Heart arrhythmia BC65 Terminated [9]
NIGULDIPINE DMSPWMF N. A. N. A. Terminated [7]
TH-9229 DMG1MPD Reperfusion injury ND56.Z Terminated [10]
CGS-27830 DM8TLY3 N. A. N. A. Terminated [11]
R-56865 DMYTI3J Angina pectoris BA40 Terminated [12]
PD-32577 DMBA15J Discovery agent N.A. Investigative [13]
CPU-228 DMM8FUT Cardiac failure BD10-BD13 Investigative [14]
(-)-(S)-BayK8644 DMEA9KH Discovery agent N.A. Investigative [14]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated calcium channel alpha Cav1.1 (CACNA1S) TT94HRF CAC1S_HUMAN Activator [2]
Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) TTZIFHC CAC1C_HUMAN Activator [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2518).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 528).
3 The calcium channel ligand FPL 64176 enhances L-type but inhibits N-type neuronal calcium currents. Neuropharmacology. 2003 Aug;45(2):281-92.
4 (-)-[3H]Desmethoxyverapamil, a novel Ca2+ channel probe. Binding characteristics and target size analysis of its receptor in skeletal muscle. FEBS Lett. 1984 Oct 29;176(2):371-7.
5 Biochemical characterization of plasma membrane isolated from human skeletal muscle. FEBS Lett. 1985 Sep 2;188(2):222-6.
6 High-affinity binding of DTZ323, a novel derivative of diltiazem, to rabbit skeletal muscle L-type Ca++ channels. J Pharmacol Exp Ther. 1997 Apr;281(1):173-9.
7 Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716.
8 Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity. J Med Chem. 1989 Oct;32(10):2399-406.
9 Design and synthesis of novel dihydropyridine alpha-1a antagonists. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8.
10 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008159)
11 CGS 27830, a potent nonpeptide endothelin receptor antagonist, Bioorg. Med. Chem. Lett. 3(10):2099-2104 (1993).
12 Novel calcium antagonists with both calcium overload inhibition and antioxidant activity. 1. 2-(3, 5-di-tert-butyl-4-hydroxyphenyl)-3-(aminopropyl)... J Med Chem. 1998 Oct 22;41(22):4309-16.
13 Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52.
14 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 529).