General Information of Drug (ID: DMBADQV)

Drug Name
ASP-3291 Drug Info
Indication
Disease Entry ICD 11 Status REF
Ulcerative colitis DD71 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMBADQV

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Drug(s) Targeting Melanocortin receptor (MCR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MT-II DMKT1DA Female sexual arousal dysfunction HA01.1 Investigative [3]
C[Nle-Arg-D-Nal(2')-Arg-Trp-Glu]-NH2 DMX7IVO Discovery agent N.A. Investigative [4]
Ac-YRMEHdFRWG-NH2 DMN2UKC Discovery agent N.A. Investigative [5]
C[Nle-Gln-D-Nal(2')-Arg-Trp-Glu]-NH2 DMM19SJ Discovery agent N.A. Investigative [4]
C[Nle-Val-D-Nal(2')-Arg-Trp-Glu]-NH2 DMSIGJW Discovery agent N.A. Investigative [4]
C[Nle-Arg-D-Phe-Arg-Trp-Glu]-NH2 DMUESCH Discovery agent N.A. Investigative [4]
Ac-YR[CEH(d-2alpha-Nal)RWC]-NH2 DMVQ4KG Discovery agent N.A. Investigative [5]
C[CO-o-C6H4-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2 DMD6OW4 Discovery agent N.A. Investigative [6]
AEKKDEGPYRMEHFRWGSPPKD DMZ8SV3 Discovery agent N.A. Investigative [5]
Ac-YRMEHdFRWGSPPKD-NH2 DMDH5B3 Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Melanocortin receptor (MCR) TTEOSZT NOUNIPROTAC Modulator [2]

References

1 ClinicalTrials.gov (NCT01612039) Safety, Efficacy, and Tolerability Study of ASP3291 in Patients With Active Ulcerative Colitis. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of Drais Pharmaceuticals.
3 Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 rece... J Med Chem. 2009 Jun 25;52(12):3627-35.
4 Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52.
5 Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8.
6 Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95.