Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTEOSZT)

• DTT Name: Melanocortin receptor (MCR)
• Synonyms: Melanocortin receptor
• Gene Name: MCR
• DTT Type: Clinical trial target; [1]
• UniProt ID: NOUNIPROTAC
• TTD ID: T45457

Molecular Interaction Atlas (MIA) of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ASP-3291	DMBADQV	Ulcerative colitis	DD71	Phase 2	[2]

39 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ac-His-DNal(2)-Arg-Trp-NH2	DMUEBRN	Discovery agent	N.A.	Investigative	[3]
Ac-His-DPhe(3,4-diCl)-Arg-Trp-NH2	DMR31Z9	Discovery agent	N.A.	Investigative	[3]
Ac-His-DPhe(pBr)-Arg-Trp-NH2	DMXU5ZP	Discovery agent	N.A.	Investigative	[3]
Ac-His-DPhe(pCF3)-Arg-Trp-NH2	DMTA6I5	Discovery agent	N.A.	Investigative	[3]
Ac-His-DPhe(pI)-Arg-Trp-NH2	DM3GSPX	Discovery agent	N.A.	Investigative	[3]
Ac-Nle-c[Asp-His-DNal(2')-Pro-Trp-Lys]-NH2	DMOVI7Y	Discovery agent	N.A.	Investigative	[4]
Ac-YRC(Me)*EHdFRWC(Me)NH2	DMWJ8UR	Discovery agent	N.A.	Investigative	[5]
Ac-YRMEHdFRWG-NH2	DMN2UKC	Discovery agent	N.A.	Investigative	[5]
Ac-YRMEHdFRWGSPPKD-NH2	DMDH5B3	Discovery agent	N.A.	Investigative	[5]
Ac-YR[CEH(d-2alpha-Nal)RWC]-NH2	DMVQ4KG	Discovery agent	N.A.	Investigative	[5]
Ac-YR[CEH(pCl-dF)RWC]-NH2	DM25JXM	Discovery agent	N.A.	Investigative	[5]
Ac-YR[CEH(pF-dF)RWC]-NH2	DMXCF9T	Discovery agent	N.A.	Investigative	[5]
AEKKDEGPYRMEHFRWGSPPKD	DMZ8SV3	Discovery agent	N.A.	Investigative	[5]
C[CO-(CH2)2-CO-Nle-D-Nal(2)-Arg-Trp-Lys]-NH2	DMHARQX	Discovery agent	N.A.	Investigative	[6]
C[CO-(CH2)2-CO-Nle-D-Phe-Arg-Trp-Lys]-NH2	DMI3CSJ	Discovery agent	N.A.	Investigative	[6]
C[CO-(CH2)3-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2	DMYPHVC	Discovery agent	N.A.	Investigative	[6]
C[CO-(CH2)3-CO-Pro-D-Phe-Arg-Trp-Lys]-NH2	DM0VP79	Discovery agent	N.A.	Investigative	[6]
C[CO-2,3-pyrazine-CO-D-Nal(2)-Arg-Trp-Lys]-NH2	DM1VCJP	Discovery agent	N.A.	Investigative	[6]
C[CO-o-C6H4-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2	DMD6OW4	Discovery agent	N.A.	Investigative	[6]
C[Nle-Arg-D-Nal(2')-Arg-Trp-Glu]-NH2	DMX7IVO	Discovery agent	N.A.	Investigative	[7]
C[Nle-Arg-D-Phe-Arg-Trp-Glu]-NH2	DMUESCH	Discovery agent	N.A.	Investigative	[7]
C[Nle-Asp-D-Nal(2')-Arg-Trp-Glu]-NH2	DM8SXLR	Discovery agent	N.A.	Investigative	[7]
C[Nle-Gln-D-Nal(2')-Arg-Trp-Glu]-NH2	DMM19SJ	Discovery agent	N.A.	Investigative	[7]
C[Nle-Gln-D-Phe-Arg-Trp-Glu]-NH2	DMSGWZE	Discovery agent	N.A.	Investigative	[7]
C[Nle-Glu-D-Nal(2')-Arg-Trp-Glu]-NH2	DMHNCAG	Discovery agent	N.A.	Investigative	[7]
C[Nle-Glu-D-Phe-Arg-Trp-Glu]-NH2	DMVWOPG	Discovery agent	N.A.	Investigative	[7]
C[Nle-His-D-Nal(2')-Arg-Trp-Glu]-NH2	DM36HBK	Discovery agent	N.A.	Investigative	[7]
C[Nle-His-D-Phe-Arg-Trp-Glu]-NH2	DM5HRNM	Discovery agent	N.A.	Investigative	[7]
C[Nle-Nle-D-Nal(2')-Arg-Trp-Glu]-NH2	DM73ZMG	Discovery agent	N.A.	Investigative	[7]
C[Nle-Nle-D-Phe-Arg-Trp-Glu]-NH2	DMDPBVS	Discovery agent	N.A.	Investigative	[7]
C[Nle-Pro-D-Nal(2')-Arg-Trp-Glu]-NH2	DMPZ4VB	Discovery agent	N.A.	Investigative	[7]
C[Nle-Pro-D-Phe-Arg-Trp-Glu]-NH2	DMZWMV0	Discovery agent	N.A.	Investigative	[7]
C[Nle-Val-D-Nal(2')-Arg-Trp-Glu]-NH2	DMSIGJW	Discovery agent	N.A.	Investigative	[7]
C[Nle-Val-D-Phe-Arg-Trp-Glu]-NH2	DM45ZLW	Discovery agent	N.A.	Investigative	[7]
GPYRMEHFRWGSPPKD-NH2	DMLRTPH	Discovery agent	N.A.	Investigative	[5]
MK-10	DMI7859	Discovery agent	N.A.	Investigative	[8]
MK-11	DM4FG32	Discovery agent	N.A.	Investigative	[8]
MT-II	DMKT1DA	Female sexual arousal dysfunction	HA01.1	Investigative	[4]
NDP-SYSMEHFRWGKPVG	DMRV16G	Discovery agent	N.A.	Investigative	[5]

References

• [1] Wikipedia: Bremelanotide
• [2] Clinical pipeline report, company report or official report of Drais Pharmaceuticals.
• [3] Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-... J Med Chem. 2008 Sep 25;51(18):5585-93.
• [4] Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 rece... J Med Chem. 2009 Jun 25;52(12):3627-35.
• [5] Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8.
• [6] Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95.
• [7] Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52.
• [8] Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors. J Med Chem. 2002 Jun 6;45(12):2644-50.