Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBF42W)

Drug Name

5'-amino-5'-deoxy-alpha-D-thymidine Drug Info

Synonyms

CHEMBL428720; BDBM50223794; ZINC17000414

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Mycobacterium Thymidine monophosphate kinase (MycB tmk)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[2]
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[3]
2'-deoxythymidine triphosphate	DM9OEJT	Discovery agent	N.A.	Investigative	[2]
Deoxythymidine	DMR90HY	Discovery agent	N.A.	Investigative	[2]
Diphosphate	DMHY30B	Discovery agent	N.A.	Investigative	[2]
Thymidine-5'-Phosphate	DMKM6NQ	Discovery agent	N.A.	Investigative	[2]
P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate	DMM4VWD	Discovery agent	N.A.	Investigative	[4]
3'-Azido-3'-Deoxythymidine-5'-Monophosphate	DMU08MN	Discovery agent	N.A.	Investigative	[2]
5-Hydroxymethyluridine-2'-Deoxy-5'-Monophosphate	DMWVCJ1	Discovery agent	N.A.	Investigative	[2]
CHLORODEOXYURIDINE	DMQT3WJ	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mycobacterium Thymidine monophosphate kinase (MycB tmk)	TT5B8AX	KTHY_MYCTU	Inhibitor	[1]

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References

1	Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacteri... J Med Chem. 2007 Nov 1;50(22):5281-92.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
4	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
5	Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial ac... Bioorg Med Chem. 2008 Jun 1;16(11):6075-85.