Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBKQSZ)

• Drug Name: TTP399 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Type 2 diabetes	5A11	Phase 2	[1]
Type-1 diabetes	5A10	Phase 1/2	[2]

• Cross-matching ID:
  PubChem CID: 54673176
  TTD Drug ID: DMBKQSZ

Molecule-Related Drug Atlas

Drug(s) Targeting Glucokinase (GCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY-2599506	DMMI0RH	Diabetic complication	5A2Y	Phase 2	[4]
AMG 151	DMGOFL3	Type-2 diabetes	5A11	Phase 2	[4]
PF-04991532	DM94NBE	Diabetic complication	5A2Y	Phase 2	[5]
GK1-399	DMLFSMX	Diabetic complication	5A2Y	Phase 2	[6]
LY-2608204	DM4EF9Y	Type-2 diabetes	5A11	Phase 2	[7]
PF-04937319	DMQMF4O	Type-2 diabetes	5A11	Phase 2	[8]
AZD1656	DMUE90I	Diabetic complication	5A2Y	Phase 2	[9]
HMS5552	DMRYM03	Type-2 diabetes	5A11	Phase 1	[10]
BMS-820132	DMCX0H7	Type-2 diabetes	5A11	Phase 1	[11]
DS-7309	DM7C4U9	Diabetic complication	5A2Y	Phase 1	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucokinase (GCK)	TTDLNGZ	HXK4_HUMAN	Activator	[3]

References

• [1] ClinicalTrials.gov (NCT02405260) Add Glucokinase Activator to Target A1c (AGATA). U.S. National Institutes of Health.
• [2] ClinicalTrials.gov (NCT03335371) Evaluation of TTP399 in Patients With Type 1 Diabetes (SimpliciT1). U.S. National Institutes of Health.
• [3] Clinical pipeline report, company report or official report of vTv Therapeutics.
• [4] This week in therapeutics Endocrine disease. SciBX 2(37); doi:10.1038/scibx.2009.1408. Sept. 24, 2009
• [5] The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats. PLoS One. 2014 May 23;9(5):e97139.
• [6] Clinical pipeline report, company report or official report of vTv Therapeutics, NCT02405260.
• [7] Clinical pipeline report, company report or official report of Eli Lilly.
• [8] Two dose-ranging studies with PF-04937319, a systemic partial activator of glucokinase, as add-on therapy to metformin in adults with type 2 diabetes. Diabetes Obes Metab. 2015 Aug;17(8):751-9.
• [9] Clinical pipeline report, company report or official report of AstraZeneca (2009).
• [10] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [11] Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities. Toxicol Pathol. 2015 Aug;43(6):825-37.
• [12] Glucokinase alternative. SciBX 6(45); doi:10.1038/scibx.2013.1279. Nov. 21 2013