Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBQ87R)

Drug Name

TAK-044 Drug Info

Synonyms

TAK 044; 2-[(2R,5S,8S,11S,14S,17R)-8-(carboxymethyl)-17-(1H-indol-3-ylmethyl)-14-(2-methylpropyl)-3,6,9,12,15,18-hexaoxo-5-[2-oxo-2-(4-phenylpiperidin-1-yl)ethyl]-11-thiophen-2-yl-1,4,7,10,13,16-hexazacyclooctadec-2-yl]acetic acid; AC1NSKOX; TAK044

Indication

Disease Entry	ICD 11	Status	REF
Renal failure	GB60-GB6Z	Discontinued in Phase 2	[1]

Cross-matching ID

PubChem CID: 123882
CAS Number: CAS 157380-72-8
TTD Drug ID: DMBQ87R

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Endothelin receptor (EDNR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clazosentan	DMQSBX4	Cerebral vasospasm	BA85.Z	Phase 3	[3]
Aprocitentan	DMEJICQ	Hypertension	BA00-BA04	Phase 2	[3]
Ro-46-2005	DMRT6FV	Hypertension	BA00-BA04	Terminated	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Endothelin receptor (EDNR)	TTCV6O0	NOUNIPROTAC	Modulator	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3913).
2	Pharmacology of a non-selective ETA and ETB receptor antagonist, TAK-044 and the inhibition of myocardial infarct size in rats. Br J Pharmacol. 1995 Mar;114(5):949-54.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETB receptors. FEBS Lett. 1993 Nov 15;334(2):210-4.