Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTCV6O0)

DTT Name Endothelin receptor (EDNR)
Synonyms Human endothelin receptor
Gene Name EDNR
DTT Type
Clinical trial target
 [1]
UniProt ID
NOUNIPROTAC
TTD ID
T68315

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clazosentan DMQSBX4 Cerebral vasospasm BA85.Z Phase 3 [1]
Aprocitentan DMEJICQ Hypertension BA00-BA04 Phase 2 [1]
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2 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
TAK-044 DMBQ87R Renal failure GB60-GB6Z Discontinued in Phase 2 [2]
Ro-46-2005 DMRT6FV Hypertension BA00-BA04 Terminated [3]
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References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Pharmacology of a non-selective ETA and ETB receptor antagonist, TAK-044 and the inhibition of myocardial infarct size in rats. Br J Pharmacol. 1995 Mar;114(5):949-54.
3 In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETB receptors. FEBS Lett. 1993 Nov 15;334(2):210-4.