Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBQWVR)

Drug Name

ARQ-751 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
RAC serine/threonine-protein kinase (AKT)	TTQ7UAP	AKT1_HUMAN; AKT2_HUMAN; AKT3_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT02761694) Vevorisertib (ARQ 751) (4440-001) as a Single Agent or in Combination With Other Anti-Cancer Agents, in Solid Tumors With PIK3CA / AKT / PTEN Mutations. U.S. National Institutes of Health.
2	Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092. PLoS One. 2015 Oct 15;10(10):e0140479.