Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBUAC6)

Drug Name

GSK4532990 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Non-alcoholic steatohepatitis	DB92.1	Phase 2	[1]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13)	TTDJYZR	DHB13_HUMAN	Silencer	[2]

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References

1	ClinicalTrials.gov (NCT05583344) 17 beta-Hydroxysteroid Dehydrogenase Type 13 Minimization for the Treatment of NASH (HORIZON): A Double-Blind, Placebo-Controlled Phase 2b Study to Evaluate the Efficacy and Safety of GSK4532990 in Adults With Pre-Cirrhotic Nonalcoholic Steatohepatitis. U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of Arrowhead Pharmaceuticals