Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBWCZR)

Drug Name

ISIS 107612 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Caspase 8 messenger RNA (CASP8 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoquinoline-1,3,4(2H)-trione	DMT4RI2	Discovery agent	N.A.	Investigative	[2]
Acetyl-Ile-Glu-Thr-Asp-aldehyde	DM1VE6S	Discovery agent	N.A.	Investigative	[3]
ISIS 107676	DMUE64H	Discovery agent	N.A.	Investigative	[1]
ISIS 107681	DMB9VFS	Discovery agent	N.A.	Investigative	[1]
ISIS 107652	DMOX8JF	Discovery agent	N.A.	Investigative	[1]
ISIS 107642	DMPR7OD	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Caspase 8 messenger RNA (CASP8 mRNA)	TT6SZNG	CASP8_HUMAN	Not Available	[1]

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References

1	US patent application no. 6,258,600, Antisense modulation of caspase 8 expression.
2	Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23.
3	Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem. 2009 Apr 23;52(8):2188-91.