Details of the Drug-Related molecule(s) Interaction Atlas

US10065972, Example 281 Drug Info

SCHEMBL18335781; BDBM273097; US10065972, Example 281; (R)-N-benzyl-1-(5-difluoromethyl-6-methyl-7-oxo-6,7-dihydro-[1,3]thiazolo[5,4-d]pyrimidin-2-yl)pyrrolidine-2-carboxamide

Cross-matching ID

PubChem CID

124152707

TTD Drug ID

DMBWJK4

General Information of Drug (ID: DMBWJK4)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Preclinical Drug(s)

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Drug(s) Targeting Kynurenine oxoglutarate transaminase II (AADAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US10065972, Example 560	DM9QCTJ	N. A.	N. A.	Patented	[1]
US8933095, 1	DMG3T7E	N. A.	N. A.	Patented	[2]
US8933095, 16	DMRN5F4	N. A.	N. A.	Patented	[2]
US10065972, Example 396	DMT8WVZ	N. A.	N. A.	Patented	[1]
US8933095, 18	DMOZ4FS	N. A.	N. A.	Patented	[3]
US8933095, 14	DMZUNJ4	N. A.	N. A.	Patented	[3]
PF-04859989	DM3U2S5	Cognitive impairment	6D71	Preclinical	[4]
BFF-122	DM6BGJ9	Cognitive impairment	6D71	Preclinical	[5]
(S)-4-(Ethylsulfonyl)benzoylalanine	DMEJYV4	Cognitive impairment	6D71	Preclinical	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Kynurenine oxoglutarate transaminase II (AADAT)	TTT3IXG	AADAT_HUMAN	Inhibitor	[1]

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References

1	Bicyclic or tricyclic heterocyclic compound. US10065972.
2	KAT II inhibitors. US8933095.
3	KAT II inhibitors. US8598200.
4	Investigating KYNA production and kynurenergic manipulation on acute mouse brain slice preparations. Brain Res Bull. 2019 Mar;146:185-191.
5	Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401.
6	Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. Neuroscience. 2009 Mar 3;159(1):196-203.