Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC3NSK)

Drug Name

MUT-056399 Drug Info

Synonyms

Fab-001; MUT-1; MUT-2; MUT-3; MUT-37307; MUT-4; FabI inhibitors (antibacterial), Mutabilis; FabI inhibitors (bacterial infection), FAB Pharma

Indication

Disease Entry	ICD 11	Status	REF
Methicillin-resistant staphylococci infection	1A00-1A09	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Staphylococcus Enoyl ACP reductase (Stap-coc fabI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AFN-1252	DMTFE9Y	Staphylococcus infection	1B5Y	Phase 2	[3]
CG-400549	DMFAKGR	Bacterial infection	1A00-1C4Z	Phase 2	[4]
Afabicin	DMFO2G5	Acute bacterial skin infection	1C41	Phase 2	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial NADH-dependent enoyl-ACP reductase (Bact fabI)	TTFKXOM	FABI_ECOLI	Modulator	[2]
Staphylococcus Enoyl ACP reductase (Stap-coc fabI)	TTZBRVL	FABI_STAA8	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021501)
2	The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7.
3	Activity of AFN-1252, a novel FabI inhibitor, against Staphylococcus aureus in an in vitro pharmacodynamic model simulating human pharmacokinetics. J Chemother. 2013 Feb;25(1):32-5.
4	In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. Antimicrob Agents Chemother. 2007 Jul;51(7):2591-3.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)