Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC5TV6)

Drug Name

TPI-287 Drug Info

Synonyms

849213-15-6; (1S,2S,4S,7S,7aR,7a1S,10aS,11aR,13aS,13bR)-1-(benzoyloxy)-4-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-5-methylhexanoyl)oxy)-2-hydroxy-5,7a1,14,14-tetramethyl-9-vinyl-2,3,4,7,7a,7a1,10a,11,11a,13,13a,13b-dodecahydro-1H-8,10,12-trioxa-2,6-methanocyclobuta[b]cyclodeca[de]naphthalene-7,13a-diyl diacetate; TPI 287; SCHEMBL10000720; DTXSID50233967; Q27273546

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Phase 2	[1]
Glioblastoma multiforme	2A00.0	Phase 2	[2]
Alzheimer disease	8A20	Phase 1	[3]
Progressive supranuclear palsy	8A00.10	Phase 1	[4]

Cross-matching ID

PubChem CID: 11564168
CAS Number: CAS 849213-15-6
TTD Drug ID: DMC5TV6

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Microtubule (MicroTu)	TT1WDO0	NOUNIPROTAC	Stabilizer	[5]

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References

1	ClinicalTrials.gov (NCT01332630) TPI 287 in Breast Cancer Metastatic to the Brain. U.S. National Institutes of Health.
2	ClinicalTrials.gov (NCT02047214) Safety & Efficacy Study of TPI 287 + Avastin in Adults With Glioblastoma That Progressed Following Prior Avastin Therapy. U.S. National Institutes of Health.
3	ClinicalTrials.gov (NCT01966666) A Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of TPI-287 in Alzheimer's Disease. U.S. National Institutes of Health.
4	ClinicalTrials.gov (NCT02133846) Safety Study of TPI-287 to Treat CBS and PSP (TPI-287-4RT). U.S. National Institutes of Health.
5	TPI-287, a new taxane family member, reduces the brain metastatic colonization of breast cancer cells. Mol Cancer Ther. 2012 Sep;11(9):1959-67.