Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC8UPL)

• Drug Name: ION532 Drug Info
• Synonyms: AZD2373

Indication

Disease Entry	ICD 11	Status	REF
Chronic kidney disease	GB61	Phase 1	[1]
Nephropathy	GC2Z	Phase 1	[2]

• Cross-matching ID: TTD Drug ID: DMC8UPL

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apolipoprotein L1 messenger RNA (APOL1 mRNA)	TTDB8PW	APOL1_HUMAN	Not Available	[3]

References

• [1] ClinicalTrials.gov (NCT05351047) A Phase I, Randomized, Single-blind, Placebo-controlled Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD2373 Following Multiple Ascending Dose Administration to Healthy Male Participants of Sub-Saharan West African Ancestry. U.S.National Institutes of Health.
• [2] ClinicalTrials.gov (NCT04269031) A Phase I, First-in-Human, Randomized, Single-blind, Placebo-controlled Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD2373 Following Single Ascending Dose Administrations to Healthy Male Subjects of African Ancestry. U.S.National Institutes of Health.
• [3] Clinical pipeline report, company report or official report of Ionis