Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCGK6X)

• Drug Name: PRO 140 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus-1 infection	1C62	Phase 2/3	[1]

• Cross-matching ID: TTD Drug ID: DMCGK6X

Molecule-Related Drug Atlas

Drug(s) Targeting C-C chemokine receptor type 5 (CCR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Maraviroc	DMTL94F	Human immunodeficiency virus infection	1C62	Approved	[3]
Vicriviroc	DMMTW9K	Human immunodeficiency virus infection	1C62	Phase 3	[4]
PRO-140	DMD1FTP	Human immunodeficiency virus infection	1C62	Phase 3	[5]
E-913	DMUHS5Q	Human immunodeficiency virus infection	1C62	Phase 3	[6]
INCB9471	DMMWC6F	Infectious disease	1A00-CA43.1	Phase 2a	[6]
Cenicriviroc	DM4V8WF	Human immunodeficiency virus infection	1C62	Phase 2	[7]
BMS-813160	DMKY638	Diabetic nephropathy	GB61.Z	Phase 2	[8]
SB-728-T	DMRWE5D	Human immunodeficiency virus infection	1C62	Phase 2	[9]
PF-232798	DM8T6KQ	Human immunodeficiency virus infection	1C62	Phase 2	[10]
GSK-706769	DMPLKAH	Human immunodeficiency virus infection	1C62	Phase 2	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-C chemokine receptor type 5 (CCR5)	TT2CEJG	CCR5_HUMAN	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT03902522) PRO 140 in Treatment-Experienced HIV-1 Subjects. U.S. National Institutes of Health.
• [2] The return of PRO 140, a CCR5-directed mAb. Curr Opin HIV AIDS. 2018 Jul;13(4):346-353.
• [3] Rapamycin enhances aplaviroc anti-HIV activity: implications for the clinical development of novel CCR5 antagonists. Antiviral Res. 2009 Jul;83(1):86-9.
• [4] HIV entry: new insights and implications for patient management. Curr Opin Infect Dis. 2009 Feb;22(1):35-42.
• [5] Agonist-induced internalization of CC chemokine receptor 5 as a mechanism to inhibit HIV replication. J Pharmacol Exp Ther. 2011 Jun;337(3):655-62.
• [6] Species selectivity of small-molecular antagonists for the CCR5 chemokine receptor. Int Immunopharmacol. 2007 Dec 5;7(12):1528-34.
• [7] The dual CCR5 and CCR2 inhibitor cenicriviroc does not redistribute HIV into extracellular space: implications for plasma viral load and intracellular DNA decline. J Antimicrob Chemother. 2015 Mar;70(3):750-6.
• [8] A dual CCR2/CCR5 chemokine antagonist, BMS-813160. Expert Opin Ther Pat. 2011 Dec;21(12):1919-24.
• [9] Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV. N Engl J Med. 2014 March 6; 370(10): 901-910.
• [10] An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798). J Med Chem. 2011 Jan 13;54(1):67-77.
• [11] Tapping into combination pills for HIV. Nat Rev Drug Discov. 2009 Jun;8(6):439-40.