Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCILV7)

Drug Name

aminobenzovesamicol Drug Info

Synonyms

compound 11 [PMID: :7702637]; M-iodobenzyltrozamicol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Vesicular acetylcholine transporter (SLC18A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
T-588	DM3M5TU	Amyotrophic lateral sclerosis	8B60.0	Discontinued in Phase 2	[2]
[3H]vesamicol	DM3MK8S	Discovery agent	N.A.	Investigative	[3]
[123I]iodobenzovesamicol	DMOZGLM	Discovery agent	N.A.	Investigative	[4]
vesamicol	DMHKUBG	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vesicular acetylcholine transporter (SLC18A3)	TTV8KWS	VACHT_HUMAN	Inhibitor	[1]

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References

1	Vesamicol analogues as sigma ligands. Molecular determinants of selectivity at the vesamicol receptor. Biochem Pharmacol. 1995 Mar 15;49(6):791-7.
2	Involvement of noradrenaline transporters in S-nitrosocysteine-stimulated noradrenaline release from rat brain slices: existence of functional Na(+)-independent transporter activity. Neurochem Int. 2001 Apr;38(4):323-31.
3	Active transport of acetylcholine by the human vesicular acetylcholine transporter. J Biol Chem. 1996 Nov 1;271(44):27229-32.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1013).