Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCOMLS)

Drug Name

APY29 Drug Info

Synonyms

1216665-49-4; APY 29; APY-29; N~2~-1h-Benzimidazol-5-Yl-N~4~-(3-Cyclopropyl-1h-Pyrazol-5-Yl)pyrimidine-2,4-Diamine; N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine; N2-(1H-benzo[d]imidazol-6-yl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine; (E)-N-(6-((5-cyclopropyl-1H-pyrazol-3-yl)imino)-1,6-dihydropyrimidin-2-yl)-1H-benzo[d]imidazol-6-amine; APY 29;APY-29; CHEMBL1231018; SCHEMBL12045464; SCHEMBL20438003; SCHEMBL21067744; EX-A305; BCP09071; MFCD28023582; s6623; ZINC40163635; AKOS024458384; DB07382; 2-N-(3H-benzimidazol-5-yl)-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine; NCGC00379217-02; NCGC00379217-03; AK547105; BS-14553; DA-47145; HY-17537; QC-11386; AB0098417; FT-0700119; J3.589.967G; Q27096602; 2,4-Pyrimidinediamine, N2-1H-benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Cross-matching ID

PubChem CID: 42627755
TTD Drug ID: DMCOMLS

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Download the Complete Related Drug List

Drug(s) Targeting Endoplasmic reticulum to nucleus signaling 1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ORIN1001	DM27RXS	Metastatic breast cancer	2C6Y	Phase 1/2	[3]
US9040714, 7	DM53Z4I	N. A.	N. A.	Patented	[4]
T8361	DM86BDS	N. A.	N. A.	Patented	[5]
US8614253, 29-1	DMJKFVU	N. A.	N. A.	Patented	[6]
US8614253, 32-5	DMSQODK	N. A.	N. A.	Patented	[5]
US8614253, 29-19	DMVI83P	N. A.	N. A.	Patented	[7]
879325-11-8	DMP04Z6	N. A.	N. A.	Patented	[4]
AC1LE05K	DMPOR3G	N. A.	N. A.	Patented	[8]
US8614253, 32-4	DMRSP2M	N. A.	N. A.	Patented	[7]
BB 0223767	DM2DT6L	N. A.	N. A.	Patented	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Endoplasmic reticulum to nucleus signaling 1 (ERN1)	TTOJ9QL	ERN1_HUMAN	Inhibitor	[2]

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References

1	Allosteric inhibition of the IRE1alpha RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31;158(3):534-48.
2	Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway. Food Chem Toxicol. 2018 Apr;114:52-60.
3	Clinical pipeline report, company report or official report of Orinove.
4	IRE-1 inhibitors. US9040714.
5	IRE-1 inhibitors. US8614253.
6	IRE-1 inhibitors. US9241942.
7	IRE-1 inhibitors. US9493435.
8	IRE-1 inhibitors. US9693992.