Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCPEBF)

Drug Name

(RS)-5-diphosphomevalonate Drug Info

Synonyms

5-Diphosphomevalonic acid; (RS)-5-diphosphomevalonate; AC1L19ES; AC1Q6T4D; SCHEMBL183248; GTPL3055; CTK0I1968; 3-hydroxy-5-{[hydroxy(phosphonooxy)phosphoryl]oxy}-3-methylpentans; 1492-08-6; 4872-34-8; 5-(Phosphonooxyphosphonyloxy)-3-hydroxy-3-methylpentanoic acid; 3-hydroxy-5-(hydroxy-phosphonooxyphosphoryl)oxy-3-methylpentanoic acid; 3-hydroxy-5-[hydroxy(phosphonooxy)phosphoryl]oxy-3-methylpentanoic acid; 6,8-Dioxa-7,9-diphosphanonanoicacid, 3,7,9,9-tetrahydroxy-3-methyl-, 7,9-dioxide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 516
CAS Number: CAS 1492-08-6
TTD Drug ID: DMCPEBF

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Mevalonate kinase (MVK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
dolichol phosphate	DM1YCQF	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mevalonate kinase (MVK)	TT5DFHW	KIME_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3055).
2	Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. Org Lett. 2006 Mar 16;8(6):1013-6.
3	Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. J Lipid Res. 1997 Nov;38(11):2216-23.