Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD0YJ5)

Drug Name
BIIB115 Drug Info
Synonyms ION306
Indication
Disease Entry ICD 11 Status REF
Spinal muscular atrophy 8B61 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMD0YJ5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting SMN1 messenger RNA (SMN1 mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
nusinersen DMRSX53 Spinal muscular atrophy 8B61 Approved [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
SMN1 messenger RNA (SMN1 mRNA) TTSVGQ5 SMN_HUMAN Not Available [2]

References

1 ClinicalTrials.gov (NCT05575011) A Randomized, Blinded, Placebo-Controlled, Phase 1 Single Ascending Dose Study in Healthy Adult Male Volunteers and an Open-Label Multiple Ascending Dose Study in Pediatric SMA Participants Previously Treated With Onasemnogene Abeparvovec (Zolgensma?) to Evaluate the Safety, Tolerability, and Pharmacokinetics of BIIB115. U.S.National Institutes of Health.
2 Clinical pipeline report, company report or official report of Ionis
3 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.