Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD2QVO)

Drug Name

2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine Drug Info

Synonyms

7-Benzyloxytryptamine; 31677-75-5; 2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine; CHEMBL460302; 2-[7-(benzyloxy)-1h-indol-3-yl]ethanamine; JOYGWYISRWPUIM-UHFFFAOYSA-N; 3-(2-AMINOETHYL)-7-BENZYLOXYINDOLE; 1H-Indole-3-ethanamine,7-(phenylmethoxy)-; B-2160; NSC92541; 7-Benzyloxytriptamine; AC1Q57HL; SCHEMBL5167328; AC1L63X1; CTK4G7564; ZINC39096; 7-Benzyloxytryptamine, free base; DTXSID60293835; 6038AH; NSC-92541; BDBM50247069; AKOS024282335; 7-(Benzyloxy)-1H-indole-3-ethanamine; MCULE-8072963757; ACM31677755; ST055630

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 260806
CAS Number: CAS 31677-75-5
TTD Drug ID: DMD2QVO

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Leukotriene A-4 hydrolase (LTA4H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bestatin	DM8L9D4	Acute myeloid leukaemia	2A60	Approved	[3]
LYS006	DMI17QR	Ulcerative colitis	DD71	Phase 2	[4]
Acebilustat	DM19UTO	Chronic blistering skin disorder	ME63.3	Phase 1	[5]
DG051	DM3I0GS	Myocardial infarction	BA41-BA43	Discontinued in Phase 2	[6]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[7]
JNJ-10392980	DMZH0K8	Discovery agent	N.A.	Investigative	[8]
4-(2-amino-1,3-thiazol-4-yl)phenol	DMH5CAQ	Discovery agent	N.A.	Investigative	[9]
2-(4-phenoxyphenoxy)ethanamine	DM7TBUJ	Discovery agent	N.A.	Investigative	[10]
3-(Benzyloxy)Pyridin-2-Amine	DM35VEI	Discovery agent	N.A.	Investigative	[7]
2-[4-(2-Piperidin-1-ylethyl)phenoxy]benzothiazole	DMMYJ3R	Discovery agent	N.A.	Investigative	[8]
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Drug(s) Targeting Long transient receptor potential channel 8 (TRPM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[11]
D-3263	DM7V2OM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
PF-05105679	DM4QPT0	Pain	MG30-MG3Z	Phase 1	[13]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[14]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[15]
5-METHOXYTRYPTAMINE	DMARCKD	Discovery agent	N.A.	Investigative	[1]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[16]
2-(5-fluoro-1H-indol-3-yl)ethanamine	DMHW5FT	Discovery agent	N.A.	Investigative	[1]
NADA	DM3ORGM	Discovery agent	N.A.	Investigative	[15]
linalool	DMGZQ5P	Discovery agent	N.A.	Investigative	[17]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leukotriene A-4 hydrolase (LTA4H)	TTXZEAJ	LKHA4_HUMAN	Inhibitor	[2]
Long transient receptor potential channel 8 (TRPM8)	TTXDKTO	TRPM8_HUMAN	Inhibitor	[1]

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References

1	5-benzyloxytryptamine as an antagonist of TRPM8. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9.
2	Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. J Med Chem. 2008 Dec 25;51(24):7882-8.
3	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
4	Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A(4) Hydrolase. J Med Chem. 2021 Feb 25;64(4):1889-1903.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	BAY x 1005 attenuates atherosclerosis in apoE/LDLR - double knockout mice. J Physiol Pharmacol. 2007 Sep;58(3):583-8.
7	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
8	Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69.
9	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
10	Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6549-52.
11	TRPV1-mediated itch in seasonal allergic rhinitis. Allergy. 2009 May;64(5):807-10.
12	Best of the 2009 AUA Annual Meeting: Highlights from the 2009 Annual Meeting of the American Urological Association, April 25-30, 2009, Chicago, IL. Rev Urol. 2009 Spring; 11(2): 82-107.
13	Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. J Pharmacol Exp Ther. 2014 Nov;351(2):259-69.
14	Effects of antagonists and heat on TRPM8 channel currents in dorsal root ganglion neuron activated by nociceptive cold stress and menthol. Neurochem Res. 2012 Feb;37(2):314-20.
15	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 500).
16	Evolution of thermal response properties in a cold-activated TRP channel. PLoS One. 2009 May 29;4(5):e5741.
17	Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45.