General Information of Drug (ID: DMD74BJ)

Drug Name
PF-05089771 Drug Info
Synonyms Nav1.7 blockers (pain), Pfizer; SCN9A blockers (pain), Pfizer/Icagen/Birkbeck; Voltage-gated sodium channel 1.7 blockers (pain), Pfizer
Indication
Disease Entry ICD 11 Status REF
Chronic pain MG30 Phase 2 [1]
Cross-matching ID
PubChem CID
46840946
CAS Number
CAS 1235403-62-9
TTD Drug ID
DMD74BJ
VARIDT Drug ID
DR01027

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
XEN-402 DMR69CG Osteoarthritis FA00-FA05 Phase 2 [3]
BIIB074 DMLV1ET Bipolar disorder 6A60 Phase 2 [4]
DSP-2230 DM0WTMD Neuropathic pain 8E43.0 Phase 1 [4]
BIIB095 DMUC6EP Pain MG30-MG3Z Phase 1 [4]
GDC0310 DMUNFEP Chronic pain MG30 Phase 1 [5]
DSP-3905 DMYHU24 Neuropathic pain 8E43.0 Phase 1 [4]
PF-05241328 DM2NTBL Pain MG30-MG3Z Phase 1 [6]
DWJ-208 DMQKDJZ Cancer related pain MG30 Phase 1 [4]
RG7893 DM1R4MQ Pain MG30-MG3Z Phase 1 [7]
PF-05186462 DMUF6W9 Pain MG30-MG3Z Phase 1 [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated sodium channel alpha Nav1.7 (SCN9A) TT4G2JS SCN9A_HUMAN Blocker [2]

References

1 ClinicalTrials.gov (NCT01529346) Efficacy Of PF-05089771 In Treating Postoperative Dental Pain. U.S. National Institutes of Health.
2 Primary erythromelalgia: a review. Orphanet J Rare Dis. 2015 Sep 30;10:127.
3 Treatment of Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker. Pain. 2012 Jan;153(1):80-5.
4 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Recent progress in sodium channel modulators for pain. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9.
7 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800041740)
8 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026875)