Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDAN0K)

• Drug Name: N-methyl-Pip-F-homoF-vinyl sulfonyl phenyl (N-methyl-Pip-F-hF-VS phi) Drug Info
• Synonyms: Donepezil Fumarate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 24801487
  TTD Drug ID: DMDAN0K

Molecule-Related Drug Atlas

Drug(s) Targeting 5-HT 7 receptor (HTR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RP5063	DMKUE8O	Schizophrenia	6A20	Phase 2	[3]
JNJ-18038683	DMV1T59	Major depressive disorder	6A70.3	Phase 2	[4]
AVN-101	DMOGFNI	Cognitive impairment	6D71	Phase 2	[5]
ATI-9242	DM6GKMU	Schizophrenia	6A20	Phase 1	[6]
PMID30124346-Compound-34TABLE4	DM2G3VE	Attention deficit hyperactivity disorder	6A05.Z	Patented	[7]
PMID30124346-Compound-13TABLE4	DMHTJVA	Attention deficit hyperactivity disorder	6A05.Z	Patented	[7]
Carbamide derivative 2	DMW5GI3	N. A.	N. A.	Patented	[8]
4-oxadiazole derivative 1	DMWFHKR	N. A.	N. A.	Patented	[8]
SB-269970	DM8WTGA	Sleep-wake disorder	7A00-7B2Z	Terminated	[9]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one	DMM9X0G	Discovery agent	N.A.	Investigative	[10]

Drug(s) Targeting Cysteine protease (CYP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MELARSOPROL	DMGUZ0W	Trypanosomiasis	1D51-1F53	Approved	[11]
K-777	DMIFCMW	Discovery agent	N.A.	Investigative	[12]
S-hexyl hexane-1-sulfinothioate	DMODS9A	Discovery agent	N.A.	Investigative	[13]
S-benzyl phenylmethanesulfinothioate	DMDUC2X	Discovery agent	N.A.	Investigative	[13]
S-isopentyl 3-methylbutane-1-sulfinothioate	DM1NXFL	Discovery agent	N.A.	Investigative	[13]
S-propyl propane-1-sulfinothioate	DMFTLY9	Discovery agent	N.A.	Investigative	[13]
ALLICIN	DMSOJ6H	Discovery agent	N.A.	Investigative	[13]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 7 receptor (HTR7)	TTO9X1H	5HT7R_HUMAN	Antagonist	[1]
Cysteine protease (CYP)	TT2SUAQ	NOUNIPROTAC	Inhibitor	[2]

References

• [1] 5-HT7 receptors. Curr Drug Targets CNS Neurol Disord. 2004 Feb;3(1):81-90.
• [2] A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother. 2007 Nov;51(11):3932-9.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity. Front Behav Neurosci. 2015 Jan 15;8:453.
• [5] AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders. J Alzheimers Dis. 2016 May 25;53(2):583-620.
• [6] Pharmacological characteristics of ATI-9242, a Novel Atypical Antipsychotic. FASEB J, April, 2010, 24(Meeting Abstract Supplement),773.12.
• [7] 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689.
• [8] Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58.
• [9] [(3)H]-SB-269970--A selective antagonist radioligand for 5-HT(7) receptors. Br J Pharmacol. 2000 May;130(2):409-17.
• [10] Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97.
• [11] On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide s... J Med Chem. 2009 Sep 24;52(18):5662-72.
• [12] Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21.
• [13] Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3.